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Image Search Results
Journal: Frontiers in Pharmacology
Article Title: Bazedoxifene Attenuates Abdominal Aortic Aneurysm Formation via Downregulation of Interleukin-6/Glycoprotein 130/Signal Transducer and Activator of Transcription 3 Signaling Pathway in Apolipoprotein E–Knockout Mice
doi: 10.3389/fphar.2020.00392
Figure Lengend Snippet: BAZ suppresses the phosphorylation of STAT3 induced by IL-6 and AngII in VSMCs. Cells were pretreated with BAZ for 2 hours and then stimulated with IL-6 (A) and AngII (E) , western blotting was used to show the expression of P-STAT3 and STAT3. (I) ELISA was used to exam the effect of AngII on the secretion of IL-6 in vitro . (J) The effect of sIL-6R at different concentrations on IL-6 signaling transduction. (N) The effect of AngII or sIL-6R on the expression of P-STAT3. (B, C, F, G, K, L, O, P) Relative gray intensity to GAPDH was calculated. (D, H, M, Q) Relative gray intensity to T–STAT3 was calculated. Data were expressed as mean ± standard error of the mean (n = 3). # P < 0.05 compared with the control; *P< 0.05, **P< 0.01compared with IL-6 or AngII.
Article Snippet: Then cell culture medium was collected for ELISA (
Techniques: Phospho-proteomics, Western Blot, Expressing, Enzyme-linked Immunosorbent Assay, In Vitro, Transduction, Control